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For both HC and patients, purine metabolites normally show significant cross-pathway correlation only with TYR, not with its metabolites, where correlations may be lost due to internal influences over neurotransmitter production

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Insulin-mediated signaling pathway The binding of insulin with its receptor (IR) can regulate the phosphoinositide-3-phosphate kinase (PI3K)/AKT pathway to induce glycogen synthesis by inhibiting the expression of glycogen synthase kinase 3 [205]