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Inhibitor of OCT2 Transporter Activity The screening of a large-scale bioactive compound library (8,086 compounds) identified the FDA-approved TKI dasatinib as a potent inhibitor of the OCT2 transporter, which is involved in oxaliplatin uptake to the DRG (Sprowl et al., 2016)

Shi X, Zhang J, Ding Y, Li H, Yao S, Hu T, Zhao C, Wang J

Gpx4 fl/fl homozygous were bilaterally injected AAV- hSyn - Cre -EGFP into the substantia nigra as described above to obtain a strain of Gpx4 CKD mice