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PQ also impairs the renal parenchyma, and causes ischemic or toxic acute tubular necrosis in the kidneys, which leads to acute kidney injuries (Bullivant, 1968

1hk), resulting in a 7-fold higher so-called HERA score for REW than the WT antibody (Fig

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In addition, artemisinin increases ROS levels, and FIN56 binds and activates squalene synthase to accumulate ROS (Kang et al., 2019), leading to the depletion of endogenous antioxidant CoQ10 and then inducing ferroptosis by lipid peroxidation