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The SS-31-modified DOX-loaded liposome delivery system LS-DOX can effectively cross the blood brain barrier (BBB) to target gliomas, and mitochondrial targeting of SS-31 can enhance cellular uptake (182)

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Section 1833(g)(5)(E) of the Act states that CMS shall identify and conduct targeted medical review using factors that may include the following: (1) The therapy provider has had a high claims denial percentage for therapy services under this part or is less compliant with applicable requirements under this title