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Theoretical concerns Copper accumulation: Each 2mg injection contributes about 0.03mg copper versus 0.9-2.2mg from daily diet

The incidence of the primary safety endpoint in patients without a history of psychiatric disorders was 1.3% (CHANTIX/CHAMPIX), 2.2% (bupropion), 2.5% (nicotine patch) and 2.4% (placebo)