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The authors also validated that GSH content and GPX4 activity were significantly decreased when H22 cells were co-incubated with Mn-MOF (Figures 5H, I)

Hence, it can be seen that many environmental pollutants are capable of inducing eryptosis in human RBCs, and that eryptosis may be an effective indicator for comparing the hematotoxicity of parent compounds and their metabolites [423], to assess the toxicity of their potential replacements [421, 422, 428], and to investigate the mechanisms of action of toxic metals [184, 420, 424, 435] and pesticides [436, 437]

Despite the inconspicuous DEGs presented in the circos plot (Fig

10.1056/NEJM199605023341814 73 IacobazziV.InfantinoV.PalmieriF