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Characterization of the initial steps in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase

At present, although some studies have shown that inorganic selenium sources, such as sodium selenite (SS), which are mainly used as dietary selenium source additives, have significant detoxification effects on mycotoxins and heavy metal poisoning [4447], they are still limited by acute toxicity, accelerated oxidation, and low bioavailability in the application process

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This heterogeneity complicates the elucidation of pharmacokinetic and pharmacodynamic profiles, particularly in compounded preparations, thereby hindering standardization and clinical validation