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2.2 Modulation of adaptive immune cells by bile acids Beyond their impact on innate immunity, bile acids (BAs) also exert profound and multifaceted regulatory effects on adaptive immune cell populations, critically shaping T cell differentiation, effector functions, and memory responses within the TIME

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In parallel, we performed a FACS-based CRISPR screen using a library of UPS-focused sgRNAs and a dual fluorescence stability reporter for the short isoform of BRD4, BRD4(S) (KBM7 cells expressing a BRD4(S)TagBFPP2AmCherry construct) (Fig