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Anticancer Res 36(11):57815792 Vredenburg G, den Braver-Sewradj S, van Vugt-Lussenburg BM, Vermeulen NP, Commandeur JN, Vos JC (2015) Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants

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However, CAR targeting has more specificity, no HLA restriction, and avoid many of the T cell escape mechanisms that are used by infectious agents and tumours are no longer effective against CAR T cells

The negative effects produced by 1 mg/kg of WIN55,212-2 are hypothesized to be due to stronger reductions in Ca 2+ influx, resulting in reduced neuronal activity, which possibly hinders activity-dependent myelination (Tomas-Roig et al., 2020)