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In this research, stimuli-responsive prodrug nanomedicines played a vital role as a drug delivery system, realizing tumor-specific therapy and reducing systemic toxicity by minimizing the exposure of healthy tissues to cytotoxic agents

Under the joint regulation of existing mitochondrial nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), new mitochondria are synthesized to replace damaged mitochondria, so as to repair mitochondrial structure, maintain mitochondrial function, increase antioxidant effect, reduce pathological oxidative stress and promote ATP production to meet the metabolic needs of eukaryotic cells under physiological and pathological conditions (Popov, 2020

Furthermore, the orphan nuclear receptor 77 can bind to the promoter region of eNOS, enhancing NO production

In a trial involving 46 cancer patients, those who received selenium (200 mcg) and vitamin E (400 IU) had less cisplatin-induced kidney toxicity than those who received placebo (Hemati 2012)