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Consequently, mitochondrial-to-mitochondrial RIRR constitutes a positive feedback mechanism that enhances ROS production, potentially resulting in severe mitochondrial and cellular damage (Fig

The mass spectrometry raw data was processed by FragPipe to search against the target protein database

Traunecker et al., Nature 331:84-86 (1988).) Fusion proteins having disulfide-linked dimeric structures (due to the IgG) can also be more efficient in binding and neutralizing other molecules, than the monomeric secreted protein or protein fragment alone