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DOI: 10.1053/ajkd.2002.33911 , 5 Lawrence RC, Felson DT, Helmick CG, et al

If a patient is allergic to allopurinol, there are often limited options

The problem is context: the near-total absence of human clinical data, contaminated supply chains, the absence of medical oversight, and an information ecosystem that systematically understates risk while overstating benefit

Clinical studies As summarized above, a multitude of preclinical studies have investigated the therapeutic effects of stimulating NAD + metabolism to ameliorate symptoms of aging and various pathologies, yielding promising results