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The mu-opioid receptor (MOR) is a G protein-coupled receptor that is associated with pain perception

AML cells are completely dependent on exogenous GLN, and knockdown of high-affinity ASCT2 leads to apoptosis in AML cell lines and inhibits tumor progression in AML xenografts and primary AML mouse models [47] Indeed, ASCT2 plays pleiotropic roles in cellular metabolism and serves as a promising molecular target for the treatment of leukemia [27]

To contextualize the need for this integrative approach, Table 1 provides a concise comparison including benefits and drawbacks between existing diagnostic and therapeutic frameworks, and the added mechanistic value offered by the proposed workflow (De Strooper and Karran, 2016

In another study, male mice were given CGA or a dietary supplement containing CGA and chromium (III)