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379 Studies using aged animal models have verified that elevating the levels of circulating OCN, GDF11, and FNDC5 is associated with an augmentation in BDNF levels and enhancement of neurogenesis

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Glutathione (GSH) and PD Brain GSH levels in patients with PD are decreased, and the dopamine D2 receptor (DRD2) in astrocytes can regulate the synthesis of GSH through pyruvate kinase isozyme type M2 (PKM2)-mediated transactivation of Nrf2

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