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Gut microbes can also convert 2-methylbutyric acid (2MBA) to 2-methylbutyrylcarnitine (2-MBC)

[53] Lucas J, Hsieh TC, Halicka HD, Darzynkiewicz Z, Wu JM

10.1073/pnas.1316569111 37

High fructose, free PA, HFD, hypoxia, ageing or disease can cause mitochondrial damage in vivo or in vitro in mammals (Reference Brand and Nicholls69Reference Marcovina, Sirtori and Peracino71)