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Modern liver-specific IGF-1 knockout studies have shown that local IGF-1 contributes substantially to tissue IGF1R activation, separate from the endocrine pool

doi: 10.3389/fimmu.2024.1455050 Received 27 June 2024 Accepted 03 December 2024 Published 17 December 2024 Volume 15 - 2024 Edited by Chris Wincup, Kings College Hospital NHS Foundation Trust, United Kingdom Reviewed by Devis Benfaremo, Marche Polytechnic University, Italy Elizabeth Spencer, Icahn School of Medicine at Mount Sinai, United States Carlo Alberto Maronese, IRCCS Ca Granda Foundation Maggiore Policlinico Hospital, Italy Adeeb Bulkhi, Umm Al Qura University, Saudi Arabia Updates Copyright 2024 Shao, Chen, Pan, Chen, Chen and Chen