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Redox Biol (2023) 62:102682

Consequently, asparaginase (ASNase)-mediated depletion of asparagine inhibits both primary tumor growth and metastasis through mechanisms involving both asparagine deprivation and glutamine depletion (85)

Important enzymes as glutathione/glutathione disulfide (GSH/GSSG) and thioredoxin (Trx) are NADPH dependent (Halliwell, 1999) which has the function to transfer electrons from NADPH to both