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l-2HG is detectable at very low levels in cells but increases when NADH/NAD + ratios are high, such as under hypoxia and ETC dysfunction (3336)

Pittenger C, Bloch MH

Liu Y, Zhang J, Li L, Yin G, Zhang J, Zheng S, Cheung H, Wu N, Lu N, Mao X, Yang L, Zhang J, Zhang L, Seth S, Chen H, Song X, Liu K, Xie Y, Zhou L, Zhao C, Han N, Chen W, Zhang S, Chen L, Cai W, Li L, Shen M, Xu N, Cheng S, Yang H, Lee J, Correa A, Fujimoto J, Behrens C, Chow C, William WN, Heymach JV, Hong WK, Swisher S , Wistuba II, Wang J, Lin D, Liu X, Futreal P, Gao Y

Molecular pathogenesis of lung squamous cell carcinoma (LUSC) Lung squamous cell carcinoma (LUSC) is assumed to develop through a series of epithelial transformations, including squamous metaplasia, dysplasia, and carcinoma in-situ (CIS), before progressing to invasive malignancy [69]