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[2] Exposure to nitrous oxide (including recreational use) can cause functional B12 deficiency and worsen neurological manifestations

But it also does not make them safe

Regulation and function of ascorbate peroxidase isoenzymes

Low levels of Vitamin B12 can lead to grave diseases such as Alzheimers, Parkinsons apart from adverse health issues like brain atrophy, cognitive impairment, impaired nerve function and depression