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The influence mediated by HGF secretion and HGF-induced MET activation in all these studies provides an evidence that, beyond stem-cell ability to differentiate into neurons, the secretion of paracrine growth factors such as HGF provides an important regenerative capacity and a promising therapeutic tool

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If offering peptides outside approved indications, clinicians should present use as experimental, disclose regulatory status and paucity of clinical studies, describe known and unknown risks, and outline standard treatment alternative (e.g

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