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This raises the interesting question of how this prominent midfacial muscle should be treated

Retrieved 2014-08-29

It is a biologically active fraction of vitamin B 12 that can be readily taken up by all cells and represents only 6% to 20% of total serum vitamin B 12 .23 In vitamin B 12 deficiency, serum level of holotranscobalamin decreases even before elevation in homocysteine and MMA levels occurs.24 It has been shown that holotranscobalamin is the most sensitive marker for vitamin B 12 deficiency, followed by MMA.23 25 Like homocysteine and MMA, holotranscobalamin cannot be tested in renal patients as its level increases in renal impairment.23 Furthermore, higher cost and lesser availability than homocysteine and MMA testing make it difficult to acquire wide clinical acceptance

If you suspect you have experienced side effects from a prescribed B12 medicine, you can report this through the MHRA Yellow Card scheme