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(2001) investigated AOD9604 in obese Zucker rats and observed that chronic administration was associated with reduced body weight gain without changes in IGF-1 levels or glucose tolerance, distinguishing its activity profile from that of full-length growth hormone [1]

In clinical trials of Wegovy (FDA-approved semaglutide), participants achieved an average weight loss of approximately 15% over 68 weeks, with some participants achieving up to 20% with continued treatment and adherence, when combined with diet and exercise

Both targeted and non-targeted data analysis was applied

10.1111/nyas.15187 22 GrantB.KeanJ.ValiN.CampbellJ.MadenL.BijralP.et al (2023b)