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Overall, these data support a model whereby hemeHPX could potentially interact with a plasma membrane HSPG, possibly by binding ligands and then presenting them, as suggested for LRP1, for endocytosis (Kanekiyo et al., 2011)

also acknowledge funding from Horizon Europe (PROTO-Advanced PeRsOnalized Therapies for Osteoarthritis-TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES, grant agreement ID: 101095635, and AM funding from ENgineered CArtilage from Nose for the Treatment of Osteoarthritis (ENCANTO), grant agreement ID: 101137315, A.M