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It reaches its highest intracellular concentrations in the parenchymal cells (hepatocytes) of the healthy liver, the organ most heavily involved in the detoxification of xenobiotics (substances foreign to the body)

Interestingly, the activity of methylating enzymes such as the S -adenosylmethionine-dependent protein arginine methyltransferase (type I) 103 responsible for the ADMA synthesis or the activity of ADMA hydrolyzing enzymes such as dimethylarginine dimethylaminohydrolase 102 are redox sensitive

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