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In addition, MOFs formed by porphyrin-like metal elements gradually release metal ions within the wound and these ions combined with oxygen anions (O 2 ) can release electrons that subsequently migrate to transition porphyrin elements to generate OH(Zhang et al., 2021c)

The mechanism through which these ingredients act probably occurs in the following manner: the biologically active ingredients in traditional Chinese medicine alter the structure of the intestinal flora, the endogenous metabolites produced by some traditional Chinese medicines with the participation of the intestinal flora play an anti-inflammatory and anti-AS effect, Chinese medicine adjusts the intestinal flora imbalance caused by AS to improve AS

Four of the other CEG members were participating investigators in the EPIC Study

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