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Familial CaLS may correspond to a form of Legius syndrome, although this has been ruled out in some cases.24 Mosaic forms of NF1 may exist exclusively with cutaneous involvement and NF1 mutations may not be detectable in circulating leukocytes.19 It may even be the case that the mutation resides in another gene of the RAS pathway.33,34 McCune-Albright syndrome is characterized by extensive CaLS, often with a unilateral segmental distribution and irregular borders

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Lemna minor was selected as a biological model to study the effects of electromagnetic radiation due to its high phenotypic plasticity in response to environmental conditions (Kendeler 1975)

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