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In severe cases, individuals may experience difficulty sleeping, performing daily activities, or lifting heavy objects

We also found that stable isotope labeling by amino acids in cell culture (SILAC) quantification was used to profile H3K4me3 interactors in some previous work 17,23 , which contributed to a relatively lower false-positive rate compared with LFQ or a tandem mass tag (TMT) quantitative analysis 39,66

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