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Furthermore, OHP causes damage to both neuronal and nonneuronal mitochondria, leading to oxidative stress burden mediated by the redox-sensitive TRPA1 channels, which correlate with OHP-induced cold and mechanical hypersensitivity [71, 115,116,117]

Free Radic Biol Med 106:111117

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Materials and Methods Animals The animal experiments were performed in accordance to the NIH Criteria for the Use of Laboratory Animals, and this study was approved by the ethics committee of the China Medical University Institutional Animal Care and Use Committee (protocol no