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The ambivalence of clinical results may be closely related to several factors: (1) differences in patient staging, as positive trials predominantly included patients with early-stage PD, while negative trials encompassed a broader range of disease stages, where neuronal damage may have become irreversible in late-stage patients (Yoritaka et al., 2018)

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N Engl J Med 382(23):22682270 Prcoveanu DFV, Pirici I, Tudoric V et al (2017) Tau protein in neurodegenerative diseases - a review

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