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Furthermore, Bax alters mitochondrial outer membrane permeabilization antagonizing the function of Bcl-2, leading to the release of bioactive substances such as Cyt-C from the intermembrane space into the cytosol (59)

In addition, the mice also showed the phenotypes of increased mitochondrial oxidative stress, histopathological changes, and abnormal mitochondrial ultrastructure in cardiomyocytes

10.1016/s1470-2045(08)70285-70287 Lancet Oncol

Iron overload enhances oxidative stress and the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome signaling, triggering the evolution of several inflammatory mediators, resulting in a cascade of inflammatory responses and renal dysfunction in iron-overloaded rats (Chaudhary et al., 2018)