The mixture was vortex-mixed and centrifuged at 4000 rpm/5 min at 4 C
For untargeted metabolite profiling in leaves of Arabidopsis during the light stress time-course experiment, plants grown in a peat pellet were exposed to 1000 mol m 2 s 1 light intensity at 22 C for a period of 0, 20, 60, and 90 s as previously described 39

Baumert 1,9 , (1)University of Strasbourg, Inserm, Institut De Recherche Sur Les Maladies Virales Et Hpatiques Umr-S1110, 67000 Strasbourg, France, (2)Cnrs, Institut Pluridisciplinaire Hubert Curien Umr 7178, Strasbourg, France, (3)Institut Hospitalo-Universitaire, Ple Hpato-Digestif, Nouvel Hpital Civil, Strasbourg, France, (4)Department of Medicine, Division of Oncology, Massachusetts General Hospital, Boston, Harvard Medical School, Boston, USA, (5)Alentis Therapeutics, Basel, Switzerland, (6)Ihu-Strasbourg, Institute of Image-Guided Surgery, Strasbourg, France, (7)Division of Chronic Inflammation and Cancer, German Cancer Research Center, Heidelberg, Germany, (8)The M3 Research Institute, (9)Institut Hospitalo-Universitaire (IHU), Ple Hpato-Digestif, Hpitaux Universitaires De Strasbourg, 67000 Strasbourg, France Background: Cholangiocarcinoma (CCA) is a highly aggressive adenocarcinoma with unsatisfactory treatment options

Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning