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The hypoxic niches contribute to the development of therapy resistance to conventional chemotherapy, which often relies on oxygen to generate reactive oxygen species (ROS) that damage cancer cells

However, as for the mitigation part, there are various chelating agents available against mercury poisoning

Science 2011;333:13037

The deletion of NCOA4 can inhibit the reduction in the level of the FTH1 protein caused by cystine deprivation, and cystine deprivation simultaneously induces the accumulation of light chain 3 (LC3)-II protein associated with microtubules, enhances ferritin phagocytosis, and then promotes ferroptosis in GBM cells (90)