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Studies in mice lacking endothelial P-selectin glycoprotein ligand-1 (PSGL-1) and ICAM-1 demonstrate a reduction in activated microglia in the brain parenchyma, indicating a bidirectional communication of inflammation activation stemming from the endothelium (Atangana et al., 2017)

Additionally, they can incorporate metabolites produced by microbes or clinical traits linked to host health, creating a more comprehensive understanding of the system complexity and microbiome balance

Haruma K, Ito M (2003) Review article: clinical significance of mucosal-protective agents: acid, inflammation, carcinogenesis and rebamipide

Eastman SJ