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Overall, our results propose a novel therapeutic strategy for APAP-induced liver injury, involving hepsin administration alongside a low dose of NAC to improve treatment effectiveness and address current limitations

These functional groups remain relatively stable in circulation but are rapidly cleaved under specific intracellular conditions to release the drug

The role of SIRT3 in homeostasis and cellular health

Data availability Data is available upon reasonable request, numerical source data for graphs in the manuscript can be found in the supplementary data file (Supplementary Source Data 1)