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The chronic pressure overload model, induced by abdominal aorta banding, leads to left ventricular hypertrophy, diminished maximal oxidative capacity, reduced activity of mitochondrial respiratory chain complex IV, increased mitochondrial H 2 O 2 production, free radical leak, and citrate synthase activity in the subendocardium and subepicardium[107]

Several reports have noted reversible cerebral atrophy and dementia in association with valproate therapy

The protein-binding rate is high in hemoglobin, while myoglobin, enzymes, and iron-transporting proteins are all lower, and ferritin or heme-containing hemoglobin is also low

Funding This work is supported by the National Natural Science Foundation of China (Nos