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This review article will cover up-to-date information about GABA-producing microorganisms isolated from human gut and food sources, explanation why those microorganisms produce GABA, food factors inducing gutGABA production, evidence suggesting GABA as a mediator linking between gut microbiota and mental health, including anxiety, depression, stress, epilepsy, autism spectrum disorder, and attention deficit hyperactivity disorder, and novel information regarding homocarnosine-a predominant brain peptide that is a putative downstream mediator of GABA in regulating brain functions

Sequencing results were analyzed using the ContigExpress software (Thermo Fisher Scientific), and compared with the NCBI database ( for H

Nutritional support, preferably through enteral tube feeding rather than parenteral nutrition, should be prioritized when oral intake is inadequate

Impaired expression of inducible nitric oxide synthase reduces the production and release of inflammatory factors TNF-1, IL-6, IL-8, and NO