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doi:10.3390/nu15030733

Circulation 137(5):422424 Cai Z et al (2023) Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis

After the first administration on Day 1, GX-G3 reached maximum serum concentration C max and then was eliminated from serum in rats and monkeys, which showed the increase with an approximately dose proportional manner in 110 mg/kg subcutaneous dose range in rats and monkeys