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doi: 10.1007/s11910-015-0547-z 162

The peptide does not suddenly become toxic at the expiration date

While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]