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doi: 10.1093/nar/gkae973 Summary Keywords copper homeostasis, cuproptosis, neurodegenerative diseases, immune response, cell death mechanisms Citation Li L, Lv L, Wang Z, Liu X, Wang Q, Zhu H, Jiang B, Han Y, Pan X, Zhou X, Ren L and Chang Z (2025) From copper homeostasis to cuproptosis: a new perspective on CNS immune regulation and neurodegenerative diseases