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(i) Group:1 include normoxia (N) considered as control that received only vehicle (ii) Group 2 : Hypoxia (H) received only vehicle and was exposed to hypoxia for 12 h (iii) Group 3: Normoxia + Quercetin (NQ) was supplemented with quercetin (50 mg/Kg BW) without hypoxia exposure (iv) Group 4: Hypoxia + Quercetin (HQ) received quercetin (50 mg/Kg BW) 1 h prior to hypoxia exposure for 12 h (v) Group 5: Normoxia + Acetazolamide (NA) was supplemented with acetazolamide (50 mg/Kg BW) without hypoxia exposure (vi) Group 6 : Hypoxia + Acetazolamide (HA) received acetazolamide (50 mg/Kg BW) 1 h prior to hypoxia exposure for 12 h

For transcriptome analysis, each sample consists of a pool of three replicates collected from independent differentiation experiments, both for iPSC and astrocyte cell types

Notably, randomized controlled trials have revealed that TCM interventions reduced mortality rates, shortened hospitalization duration, and mitigated postoperative complications in AP patients compared to conventional therapies (Qiong et al., 2005)

Physical examination shows hyperelasticity of the skin and hyperextensibility of the joints