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Description

5.2 Liver Injury There have been rare postmarketing reports of severe liver injury with hepatocellular necrosis or acute hepatic failure in patients treated with ORLISTAT, with some of these cases resulting in liver transplant or death

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Upon activation, choline dehydrogenase (CHDH) accumulates on the outer mitochondrial membrane (OMM), interacts with p62, and recruits autophagy adapters to depolarized mitochondria