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Peripheral neuropathy: this is a condition that can cause damage to the nerves in the hands and feet, resulting in symptoms such as pain, numbness, and weakness

Common areas affected by loose skin include the face and neck, where gravitational pull creates jowls and sagging along the jawline

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Five mitochondrial enzymes are known to require lipoylation for catalysisthe PDHc, 2-oxoglutarate dehydrogenase complex (OGDHc), 2-oxoadipate dehydrogenase complex (OADHc), branched-chain -ketoacid dehydrogenase complex (BCKDHc) and the glycine cleavage system complex (GCVc)