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Fatigue is one of the most disabling complaints of MS patients, affecting up to 80% over the disease course (Chalah et al., 2015

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Evidence-based guidelines from ASCO regarding the management of ir-nAEs including continued therapy for most grade 1 toxicity, holding treatment until recovery for most grade 2 adverse events, corticosteroid use for grade 3 toxicity and permanent discontinuation for grade 4 adverse events

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