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The development of novel targeted therapies against antioxidant pathways may yield considerable benefits to the field of cancer treatment

Past and Recently Developed Boron Delivery Agents After the first efforts, during the 1940s and 1950s, using the simplest boron salts including disodium tetraborate and sodium pentaborate, it became clear that a selective and high boron accumulation in tumor cells is crucial for an application in BNCT (Farr et al., 1958)