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Additionally, we highlight key limitations inherent to existing approaches and discuss potential strategies to overcome these barriers and improve therapeutic outcomes

AstrocyteNeuron Interaction via the GlutamateGlutamine Cycle and Its Dysfunction in Tau-Dependent Neurodegeneration

7.2 Translational gaps in antioxidant-based interventions Clinical evidence supporting pharmacological antioxidants such as melatonin, coenzyme Q10, N-acetylcysteine, and dietary polyphenols remains limited and heterogeneous