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Besides, AC591, as a standardized extract of HGWD, effectively alleviated cold hyperalgesia, mechanical allodynia, and morphological damage of DRG in OXA-treated rats ( Active ingredients of traditional medicine, such as curcumin (CUR), AC591, rosmarinic acid, quercetin, and rutin have also been studied for the prevention and treatment of PIPN

Jiang H, Liang C, Liu X, Jiang Q, He Z, Wu J, Pan X, Ren Y, Fan M, Li M, Wu Z (2010) Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways

In the latter case, the glutamate-induced oxidative stress is caused by an inhibition of the glutamate-cystine antiporter and subsequent promotion of cystine efflux and/or blockade of cystine uptake, which then results in reduction of intracellular glutathione and accumulation of intracellular ROS, and ultimately, oxidative cytotoxicity 35,36,37,38

These genes harbor mutations that affect various biological pathways, including complement regulation, lipid metabolism, extracellular collagen matrix, angiogenesis, and all- trans -retinaldehyde metabolism, to name a few