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Validation of carbon monoxide release role and chromatin modifying capability by CO-rich AuNPs Driven by the recognition that rapamycin significantly reduces the angiogenic activity of astrocytes when exposed to the CO donor CORM-2, a reduction attributed to the decreased protein level of HIF-1 induced by CORM-2 [69], we were compelled to develop further experiments to associate the pro-angiogenic effect in ECFC to the intracellular CO release of the COR-AuNPs