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Targeted CRISPR-Cas9 screens under compartment-specific GSH limitation To investigate compartment-specific vulnerabilities in cells with uncoupled mitochondrial and cytosolic GSH pools, we performed a metabolism-targeted CRISPR-Cas9 screen in Jurkat cells expressing GshF or mito-GshF in which the recently identified mitochondrial GSH transporter, SLC25A39, was knocked out (Fig

CHU, BS, PharmD, BCACP, CACP, AE-C HELENE C

As a classification of neurodegenerative diseases, is characterized by the gradual degeneration of retinal ganglion cells (RGCs) and axons (96)

For example, viruses HPV-1, HPV-2, HPV-3, HPV-4, and HPV-27 are associated with benign cutaneous lesions