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Indeed, the cytosolic redox potential measured by roGFP was more oxidizing in both glutathione-decient cad2 and in GR-decient gr1 mutants in which the GSH-GSSG ratio but not the glutathione concentration is decreased (Meyer et al., 2007

SHMT2 has also been reported to be highly expressed in the pseudopalisading cells that surround ischemic necrotic foci in human GBM [13]

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Cells have evolved a complex antioxidant system, formed by enzymatic antioxidants, such as superoxide dismutases (SODs), catalase (CAT) and glutathione peroxidases (GPXs), thioredoxin (Trx) as well as low molecular antioxidants, whose concerted action is balancing the level of oxidative stress (Halliwell 2022)