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Disagreements were resolved through discussion or by consultation with a fourth author (CS)

This approach ensures that the nanomaterial will be activated primarily in the vicinity of pathogenic bacteria, which thrive in such environments and will remain inactive in the more neutral pH of healthy tissues, pH-responsive NPs are commonly made using materials like chitosan, which undergoes protonation in acidic conditions, leading to a release of encapsulated drugs or antimicrobial agents at infection sites

But this broad utility is precisely where the critical distinction arises in GHK-Cu vs GHK-Cu Cosmetic

The hydrolysis of drugs containing the amide group is very slow while the hydrolysis of the ester group is faster [8]